Evaluation of possible role of fluoride in pathogenesis of oral submucous fibrosis: A pilot study.
Gururaj ArakeriVishal Rao UsShekar PatilSateesh KunigalRoopa ReddyMurugesan KrishnanBeverley HalePeter A BrennanPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2024)
The preliminary findings demonstrated increased tissue fluoride levels in OSMF patients compared with healthy controls. Along with a previous study showing high fluoride content in smokeless tobacco products, these findings provided early evidence suggesting fluoride could play a contributory role in OSMF pathogenesis. Further large-scale investigation is warranted to definitively establish whether the association between fluoride exposure and OSMF is indicative of causation.