The ciliary protein IFT88 controls post-natal cartilage thickness and influences development of osteoarthritis.
Clarissa R CoveneyLinyi ZhuJadwiga Miotla-ZarebskaBryony StottIda ParisiVicky BatchelorClaudia DuarteEmer ChangEleanor McSorleyTonia L VincentAngus Kt WannPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Our results demonstrate that IFT88 is chondroprotective, regulating AC thickness, potentially by thresholding a Hh response to physiological loading that controls cartilage calcification.