FNDC4 reduces hepatocyte inflammatory cell death via AMPKα in metabolic dysfunction-associated steatotic liver disease.

Gabriela NeiraSara BecerrilVíctor ValentíRafael MoncadaVictoria CatalánJavier Gómez-AmbrosiInmaculada ColinaCamilo SilvaJavier EscaladaGema FrühbeckAmaia Rodríguez

Published in: Clinical nutrition (Edinburgh, Scotland) (2024)

FNDC4 acts as a hepatocyte survival factor favouring mitochondrial homeostasis and decreasing inflammatory cell death via AMPKα. Collectively, our study identifies FNDC4 as an attractive target to prevent hepatocellular damage in patients with MASLD.

Keyphrases

cell death
oxidative stress
skeletal muscle
cell cycle arrest
liver injury
genome wide
protein kinase
drug induced
gene expression
cell proliferation