Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma.

Jiabin CaiLei ChenZhou ZhangXinyu ZhangXingyu LuWeiwei LiuGuoming ShiYang GePingting GaoYuan YangAiwu KeLinlin XiaoRuizhao DongYanjing ZhuXuan YangJiefei WangTongyu ZhuDeping YangXiaowu HuangChengjun SuiShuangjian QiuFeng ShenHuichuan SunWeiping ZhouJian ZhouJi NieChang ZengEmily Kunce StroupXu ZhangBrian C-H ChiuWan Yee LauChuan HeHong-Yang WangWei ZhangJia Fan

Published in: Gut (2019)

We have developed and validated a non-invasive approach with clinical application potential for the early detection of HCC that are still surgically resectable in high risk individuals.

Keyphrases

genome wide
dna methylation
high resolution
locally advanced
liver metastases
high density
copy number
human health
squamous cell carcinoma
radiation therapy
mass spectrometry