Correlation between the pronucleus size and the potential for human single pronucleus zygotes to develop into blastocysts : 1PN zygotes with large pronuclei can expect an embryo development to the blastocyst stage that is similar to the development of 2PN zygotes.
Eri ArakiFumiaki ItoiHiroyuki HonnmaYukiko AsanoHisanori OguriKazuyo NishikawaPublished in: Journal of assisted reproduction and genetics (2018)
The developmental potential of 1PN zygotes with large pronuclear areas (≥ 710 μm2) or diameters (31 μm) appears to be similar to that of 2PN zygotes, and measurement of pronuclear area or diameter in 1PN zygotes is a simple, potentially useful, clinical method.