Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae.

Zoe SwankYasmeen SenussiZachary Manickas-HillXu G YuJonathan Z LiGalit AlterDavid R Walt

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

The diagnosis of post-acute sequelae of COVID-19 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and COVID-19 patients to quantify viral antigens and inflammatory markers. We detect SARS-CoV-2 spike predominantly in PASC patients up to 12 months post-diagnosis.

Keyphrases

sars cov
respiratory syndrome coronavirus
liver failure
end stage renal disease
respiratory failure
ejection fraction
newly diagnosed
drug induced
chronic kidney disease
coronavirus disease
healthcare
aortic dissection
peritoneal dialysis
prognostic factors
dendritic cells
patient reported outcomes
immune response