Insular cortex stimulation alleviates neuropathic pain via ERK phosphorylation in neurons.

Kyeongmin KimGuanghai NanLeejeong KimMinjee KwonKyung Hee LeeMyeounghoon Cha Bae Hwan Lee

Published in: CNS neuroscience & therapeutics (2023)

These results indicated that ICS attenuated neuropathic pain by the regulation of pERK in neurons located in layers 2-3 of the IC. This preclinical study may enhance the potential use of ICS and identify the therapeutic mechanisms of ICS in neuropathic pain.

Keyphrases

neuropathic pain
spinal cord
spinal cord injury
signaling pathway
cell proliferation
functional connectivity
pi k akt
mouse model
cell therapy
mesenchymal stem cells
stem cells
human health
risk assessment
protein kinase
climate change