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Decline in attention-deficit hyperactivity disorder traits over the life course in the general population: trajectories across five population birth cohorts spanning ages 3 to 45 years.

Robyn E WoottonLucy RiglinRachel BlakeyJessica Agnew-BlaisArthur CayeTim CadmanAlexandra HavdahlHelen Denise Gonçalves da SilvaAna M B MenezesFernando C WehrmeisterKaili RimfeldGeorge Davey SmithThalia C EleyLuis Augusto RohdeLouise ArseneaultTerrie E MoffittEvie StergiakouliAnita ThaparKate Tilling
Published in: International journal of epidemiology (2022)
ADHD trait scores declined from childhood to mid-life, with marked variation between cohorts. Our results highlight the importance of taking a developmental perspective when considering typical population traits. When interpreting changes in clinical cohorts, it is important to consider the pattern of expected change within the general population, which is influenced by cultural context and measurement.
Keyphrases
  • attention deficit hyperactivity disorder
  • autism spectrum disorder
  • genome wide
  • working memory
  • depressive symptoms
  • dna methylation
  • early life
  • preterm birth