AtheroSpectrum Reveals Novel Macrophage Foam Cell Gene Signatures Associated With Atherosclerotic Cardiovascular Disease Risk.
Chuan LiLili QuAlyssa Joyce MatzPatrick A MurphyYongmei LiuAni W ManichaikulDerek AguiarStephen S RichDavid M HerringtonDavid VuW Craig JohnsonJerome I RotterWendy S PostAnthony T VellaAnnabelle RodriguezBeiyan ZhouPublished in: Circulation (2021)
Our novel computational program (AtheroSpectrum) identified a specific gene expression profile associated with inflammatory macrophage foam cells. A subset of 30 genes expressed in circulating monocytes jointly contributed to prediction of symptomatic atherosclerotic vascular disease. Incorporating a pathogenic foaming gene set with known risk factors can significantly strengthen the power to predict ASCVD risk. Our programs may facilitate both mechanistic investigations and development of therapeutic and prognostic strategies for ASCVD risk.
Keyphrases
- genome wide
- cardiovascular disease
- risk factors
- genome wide identification
- copy number
- adipose tissue
- type diabetes
- induced apoptosis
- dna methylation
- stem cells
- oxidative stress
- cell proliferation
- transcription factor
- dendritic cells
- immune response
- coronary artery disease
- cell cycle arrest
- pi k akt
- endoplasmic reticulum stress