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Cabozantinib Enhances Anti-PD1 Activity and Elicits a Neutrophil-Based Immune Response in Hepatocellular Carcinoma.

Roger Esteban-FabróCatherine E WilloughbyMarta Piqué-GiliCarla MontironiJordi Abril-FornagueraJudit PeixLaura TorrensAgavni MesropianUgne BalaseviciuteFrancesc Miró-MurVincenzo MazzaferroRoser PinyolJosep M Llovet
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Cabozantinib in combination with anti-PD1 enhanced antitumor immunity by bringing together innate neutrophil-driven and adaptive immune responses, a mechanism of action which favors this approach for HCC treatment.
Keyphrases
  • immune response
  • dendritic cells
  • toll like receptor
  • metastatic renal cell carcinoma
  • combination therapy