Metastasectomy of spinal lesions from thyroid carcinomas.
Satoshi KatoSatoru DemuraNoriaki YokogawaTakaki ShimizuMotoya KobayashiYohei YamadaHideki MurakamiHiroyuki TsuchiyaPublished in: The bone & joint journal (2023)
Patients with differentiated thyroid carcinomas (DTCs) have a favourable long-term survival. Spinal metastases (SMs) cause a decline in performance status (PS), directly affecting mortality and indirectly preventing the use of systemic therapies. Metastasectomy is indicated, if feasible, as it yields the best local tumour control. Our study aimed to examine the long-term clinical outcomes of metastasectomy for SMs of thyroid carcinomas. We collected data on 22 patients with DTC (16 follicular and six papillary carcinomas) and one patient with medullary carcinoma who underwent complete surgical resection of SMs at our institution between July 1992 and July 2017, with a minimum postoperative follow-up of five years. The cancer-specific survival (CSS) from the first spinal metastasectomy to death or the last follow-up was determined using Kaplan-Meier analysis. Potential factors associated with survival were evaluated using the log-rank test. We analyzed the clinical parameters and outcome data, including pre- and postoperative disability (Eastern Cooperative Oncology Group PS 3), lung and non-spinal bone metastases, and history of radioiodine and kinase inhibitor therapies. Lung and other bone metastases at the time of surgery were observed in ten and eight patients, respectively. Three patients experienced local tumour recurrences at the operated site. The five- and ten-year CSS rates in the 22 patients with DTC were 77% and 52%, respectively. Pre- and postoperative disability and operative site tumour recurrence were identified as risk factors for short postoperative survival. Metastasectomy for resectable SM from DTC yielded favourable results and has the potential to improve survival.
Keyphrases
- end stage renal disease
- patients undergoing
- spinal cord
- ejection fraction
- chronic kidney disease
- free survival
- high grade
- multiple sclerosis
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- machine learning
- electronic health record
- squamous cell carcinoma
- type diabetes
- patient reported outcomes
- radiation therapy
- risk assessment
- atrial fibrillation
- risk factors
- papillary thyroid
- drug induced