A Randomized Phase IIb Study of Low-dose Tamoxifen in Chest-irradiated Cancer Survivors at Risk for Breast Cancer.
Smita BhatiaMelanie R PalomaresLindsey HagemanYanjun ChenWendy LandierKandice SmithHeidi UmphreyCaroline A ReichKathryn W ZamoraSaro H ArmenianTherese B BeversAnne BlaesTara HendersonDavid HodgsonMelissa M HudsonLarissa A KordeSusan A MelinSofia D MerajverLinda OverholserSandhya PruthiF Lennie WongJudy E GarberPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
In this randomized trial in chest-irradiated cancer survivors, we find that low-dose tamoxifen is effective in reducing established biomarkers of breast cancer risk and could serve as a risk-reduction strategy.