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Bronchial inflammation biomarker patterns link humoral immunodeficiency with bronchiectasis-related small airway dysfunction.

Ulrich M ZisslerAljoscha ThronJonas EckrichShahrzad BakhtiarRalf SchubertStefan Zielen
Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2022)
In spite of immunoglobulin substitution, bronchial inflammation was dominated by neutrophils and was highly increased in patients with ID + BE. Notably, the pro-inflammatory cytokines in patients with ID were significantly increased in induced sputum. The context-dependent cytokine pattern in relation to the presence of concomitant bronchiectasis associated with SAD in ID patients could be helpful in delimiting ID patient subgroups and individualizing therapeutic approaches.
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