Breast cancer risk prediction using a polygenic risk score in the familial setting: a prospective study from the Breast Cancer Family Registry and kConFab.
Hongyan LiBingjian FengAlexander MironXiaoqing ChenJonathan BeesleyEmmanuella BimehDaniel BarrowdaleEsther M JohnMary B DalyIrene L AndrulisSaundra S BuysPeter Kraftnull nullHeather ThorneGeorgia Chenevix-TrenchMelissa C SoutheyAntonis C AntoniouPaul A JamesMary Beth TerryKelly-Anne PhillipsJohn L HopperGillian MitchellDavid E GoldgarPublished in: Genetics in medicine : official journal of the American College of Medical Genetics (2016)
Including BC-associated SNPs in risk assessment can provide more accurate risk prediction than family history alone and can influence recommendations for cancer screening and prevention modalities for high-risk women.Genet Med 19 1, 30-35.
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