Breast Tumor Microenvironment in Black Women: A Distinct Signature of CD8+ T-Cell Exhaustion.
Song YaoTing-Yuan David ChengAhmed M ElkhananyLi YanAngela R OmilianScott I AbramsSharon EvansChi-Chen HongQianya QiWarren DavisSong LiuElisa V BanderaKunle OdunsiKazuaki TakabeThaer KhouryChristine B AmbrosonePublished in: Journal of the National Cancer Institute (2022)
Our findings of a distinct exhausted CD8+ T-cell signature in Black breast cancer patients indicate an immunobiological basis for their more aggressive disease and a rationale for the use of immune checkpoint inhibitors targeting the exhaustion phenotype.