Ganglioside GM3 Protects Against Abdominal Aortic Aneurysm by Suppressing Ferroptosis in Vascular Smooth Muscle Cells.

Fangni ZhangKan LiWenhui ZhangZiyan ZhaoFangyuan ChangJie Du Xu Zhang Kaiwen BaoChunyong ZhangLei ShiZongwei Liu Xiangchen Dai Chen Chen Dao-Wen Wang Zhong XianHongfeng JiangDing Ai

Published in: Circulation (2023)

Together, these results suggest that GM3 dysregulation promotes ferroptosis of vascular SMCs in AAA. Furthermore, GM3 may constitute a new therapeutic target for AAA.

Keyphrases

vascular smooth muscle cells
abdominal aortic aneurysm
cell death
angiotensin ii