Microbiomics, Metabolomics, Predicted Metagenomics, and Hepatic Steatosis in a Population-Based Study of 1,355 Adults.

Louise Johanna Maria AlferinkDjawad RadjabzadehNicole Stephanie ErlerDina VojinovicCarolina Medina-GomezAndré G UitterlindenRobert J de KnegtNajaf AminM Arfan IkramHarry L A JanssenJessica C Kiefte-de JongHerold J MetselaarCornelia M van DuijnRobert KraaijSarwa Darwish Murad

Published in: Hepatology (Baltimore, Md.) (2021)

We confirmed, on a large-scale, the lower microbial diversity and association of Coprococcus and Ruminococcus Gnavus with steatosis. We additionally showed that steatosis and alpha diversity share opposite metabolic profiles.

Keyphrases

insulin resistance
high fat diet
high fat diet induced
mass spectrometry
microbial community
adipose tissue
metabolic syndrome
type diabetes
skeletal muscle