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Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge.

Christopher M SchaferSilvia Martin-AlmedinaKatarzyna KurylowiczNeil P DuftonLourdes Osuna-AlmagroMeng-Ling WuCharmain F JohnsonAarti V ShahDorian O HaskardAndrianna BuxtonErika WillisKate WheelerSean TurnerMagdalena ChlebiczRizaldy P ScottSusan KovatsAudrey CleurenGraeme M BirdseyAnna M RandiCourtney T Griffin
Published in: bioRxiv : the preprint server for biology (2023)
Collectively, our data highlight a unique role for ERG in pulmonary vascular function. We propose that cytokine-induced ERG degradation and subsequent transcriptional changes in lung ECs play critical roles in the destabilization of pulmonary blood vessels during infectious diseases.
Keyphrases
  • pulmonary hypertension
  • transcription factor
  • infectious diseases
  • gene expression
  • electronic health record
  • high glucose
  • diabetic rats
  • drug induced
  • dna binding
  • machine learning
  • data analysis