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Adiposity, Dysmetabolic Traits, and Earlier Onset of Female Puberty in Adolescent Offspring of Women With Gestational Diabetes Mellitus: A Clinical Study Within the Danish National Birth Cohort.

Louise G GrunnetSusanne HansenLine HjortCamilla M MadsenFreja B KampmannAnne Cathrine B ThuesenCharlotta GranstrømiMarin StrømEkaterina MaslovaRuth Frikke-SchmidtPeter DammJorge E ChavarroFrank B HuSjurdur F OlsenAllan Vaag
Published in: Diabetes care (2017)
In summary, adolescent offspring of women with GDM show increased adiposity, an adverse cardiometabolic profile, and earlier onset of puberty among girls. Increased fasting glucose and HOMA-IR levels among the offspring of mothers with GDM may be explained by the programming effects of hyperglycemia in pregnancy.
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