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A large French case-control study emphasizes the role of rare Mc1R variants in melanoma risk.

Hui-Han HuMériem BenfoddaNicolas DumazSteven GazalVincent DescampsAgnès BourillonNicole Basset-SeguinAngélique RiffaultKhaled EzzedineMartine BagotArmand BensussanPhilippe SaiagBernard GrandchampNadem Soufir
Published in: BioMed research international (2014)
This work confirms the role of R and r alleles in melanoma risk in the French population and proposes a novel class of rare D variants as important melanoma risk factors. These findings may improve the definition of high-risk subjects that could be targeted for melanoma prevention and screening.
Keyphrases
  • risk factors
  • skin cancer
  • copy number
  • drug delivery
  • dna methylation