A large French case-control study emphasizes the role of rare Mc1R variants in melanoma risk.
Hui-Han HuMériem BenfoddaNicolas DumazSteven GazalVincent DescampsAgnès BourillonNicole Basset-SeguinAngélique RiffaultKhaled EzzedineMartine BagotArmand BensussanPhilippe SaiagBernard GrandchampNadem SoufirPublished in: BioMed research international (2014)
This work confirms the role of R and r alleles in melanoma risk in the French population and proposes a novel class of rare D variants as important melanoma risk factors. These findings may improve the definition of high-risk subjects that could be targeted for melanoma prevention and screening.