Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia.

Gemma SalvadóMichel J GrotheColin GrootAlexis MoscosoMichael SchöllJuan Domingo GispertRik Ossenkoppelenull null

Published in: European journal of nuclear medicine and molecular imaging (2021)

Our data suggest that the established protective effect of the APOE-ε2 allele against developing clinical AD is primarily linked to resistance against Aβ deposition rather than tau pathology.

Keyphrases

cognitive decline
mild cognitive impairment
high fat diet
cerebrospinal fluid
computed tomography
physical activity
electronic health record
pet ct
adipose tissue
big data
community dwelling
type diabetes
middle aged
pet imaging
skeletal muscle