A Phase I Dose Escalation Study of Once-Weekly Oral Administration of Docetaxel as ModraDoc001 Capsule or ModraDoc006 Tablet in Combination with Ritonavir.
Vincent A de WegerFrederik E StuurmanStijn L W KoolenJohannes J MoesJeroen J M A HendrikxEmilia SawickiBas ThijssenMarianne KeessenHilde RosingMarja Mergui-RoelvinkAlwin D R HuitemaBastiaan NuijenJos H BeijnenJan H M SchellensSerena MarchettiPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Oral administration of once-weekly docetaxel as ModraDoc001 capsule or ModraDoc006 tablet in combination with ritonavir is feasible. The RP2D for both formulations is 60-mg ModraDoc with 100-mg ritonavir. Antitumor activity is considered promising.