Login / Signup

An artificial nickel chlorinase based on the biotin-streptavidin technology.

Kun YuKailin ZhangRoman P JakobTimm MaierThomas R Ward
Published in: Chemical communications (Cambridge, England) (2024)
Herein, we report on an artificial nickel chlorinase (ANCase) resulting from anchoring a biotinylated nickel-based cofactor within streptavidin (Sav). The resulting ANCase was efficient for the chlorination of diverse C(sp 3 )-H bonds. Guided by the X-ray analysis of the ANCase, the activity of the artificial chlorinase could be significantly improved. This approach opens interesting perspectives for late-stage functionalization of organic intermediates as it complements biocatalytic chlorination strategies.
Keyphrases