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SETD8, a frequently mutated gene in cervical cancer, enhances cisplatin sensitivity by impairing DNA repair.

Xin WangChen CaoXiangyu TanXueyao LiaoXiaofang DuXueqian WangTing LiuDanni GongZheng HuXun Tian
Published in: Cell & bioscience (2023)
SETD8 was a promising therapeutic target to ameliorate cisplatin resistance and improve the efficacy of chemotherapy.
Keyphrases
  • dna repair
  • dna damage
  • dna damage response
  • copy number
  • genome wide
  • genome wide identification
  • squamous cell carcinoma
  • oxidative stress
  • gene expression
  • transcription factor
  • wild type