Germline Susceptibility to Renal Cell Carcinoma and Implications for Genetic Screening.

Kate I GlennonMikiko EndoYoshiaki UsuiYusuke IwasakiRodney H BreauAnil KapoorMark LathropSimon TanguayYukihide Momozawa Yasser Riazalhosseini

Published in: JCO precision oncology (2024)

are associated with risk of metastasis. Globally, clinical guidelines for genetic screening in RCC fail to include more than 70% of patients with rare germline PVs.

Keyphrases

renal cell carcinoma
dna repair
genome wide
copy number
clinical practice
gene expression
dna methylation
dna damage
oxidative stress