A rare case with fetal autoimmune heart block and KNCH2 variant-induced long QT syndrome: a controversial opinion on prenatal management strategy.
Li WeiJiahao WuPeihuan XieXiaoliang LiuYimin HuaKaiyu ZhouChuan WangYifei LiPublished in: BMC cardiovascular disorders (2023)
For fetuses with autoimmune-mediated AVB, intrauterine treatment should still be pursued immediately. However, once the treatment outcomes are deemed unacceptable or unexpected, other genetic variant-related channelopathies should be highly suspected. If the fetus lacks a positive family history, fetal genetic testing should be recommended to improve the prognosis of such patients by introducing integrative therapeutic strategies between the prenatal and postnatal phases.
Keyphrases
- rare case
- drug induced
- end stage renal disease
- pregnant women
- multiple sclerosis
- chronic kidney disease
- newly diagnosed
- ejection fraction
- preterm infants
- gene expression
- atrial fibrillation
- peritoneal dialysis
- high glucose
- pulmonary embolism
- prognostic factors
- diabetic rats
- genome wide
- copy number
- oxidative stress
- gestational age
- patient reported outcomes
- stress induced