Investigation of selective glucocorticoid receptor modulation in high-grade serous ovarian cancer PDX models.
Manisha TayaXiaonan HouJennifer T VenerisNina KaziMelissa C LarsonMatthew John MaurerEthan P HeinzenHao ChenRicardo R LastraAnn L ObergJohn S WerohaGini F FlemingSuzanne D ConzenPublished in: Journal of gynecologic oncology (2024)
The significant improvement in PFS shown in 1 of the 6 models after treatment with a SGRM plus chemotherapy underscores the need to determine predictive biomarkers for SGRM therapy in HGS OvCa and to better identify patient subgroups that are most likely to benefit from adding GR modulation to chemotherapy.