Investigation of selective glucocorticoid receptor modulation in high-grade serous ovarian cancer PDX models.

Manisha Taya Xiaonan Hou Jennifer T Veneris Nina Kazi Melissa C Larson Matthew John Maurer Ethan P Heinzen Hao Chen Ricardo R Lastra Ann L Oberg John S Weroha Gini F Fleming Suzanne D Conzen

Published in: Journal of gynecologic oncology (2024)

The significant improvement in PFS shown in 1 of the 6 models after treatment with a SGRM plus chemotherapy underscores the need to determine predictive biomarkers for SGRM therapy in HGS OvCa and to better identify patient subgroups that are most likely to benefit from adding GR modulation to chemotherapy.

Keyphrases

high grade
low grade
locally advanced

case report
squamous cell carcinoma
rectal cancer

chemotherapy induced
radiation therapy
stem cells

bone marrow
cell therapy
smoking cessation