Modeling tumor growth with peridynamics.

Computational models of tumors have the potential to connect observations made on the cellular and the tissue scales. With cellular scale models, each cell can be treated as a discrete entity, while tissue scale models typically represent tumors as a continuum. Though the discrete approach often enables a more mechanistic and biologically driven description of cellular behavior, it is often computationally intractable on the tissue scale. Here, we adapt peridynamics, a theoretical and computational approach designed to unify the mechanics of discrete and continuous media, for the growth of biological materials. The result is a computational model for tumor growth that can represent either individual cells or the tissue as a whole. We take advantage of the flexibility provided by the peridynamic framework to implement a cell division mechanism, motivated by the fact that cell division is the mechanism driving tumor growth. This paper provides a general framework for implementing a new tumor growth modeling technique.