Induction of long-term hyperexcitability by memory-related cAMP signaling in isolated nociceptor cell bodies.
Alexis BavencoffeMichael Y ZhuSanjay V NeerukondaKayla N JohnsonCarmen W DessauerEdgar T WaltersPublished in: bioRxiv : the preprint server for biology (2024)
Nociceptor long-term hyperexcitability (LTH) can be induced by a 5-HT4R agonist.5-HT4R-induced LTH manifests as ongoing activity during modest depolarization.Enhanced ongoing activity is associated with long-term potentiation of DSFs.Induction of LTH depends upon PKA, CREB, transcription, and protein synthesis.Nociceptor LTH may be triggered by conserved memory-related plasticity mechanisms.