Autologous human preclinical modeling of melanoma interpatient clinical responses to immunotherapeutics.

Yee Peng PhoonJared E LopesLukas W PfannenstielClaudia Marcela Diaz-MonteroYe F TianMarc S Ernstoff Pauline FunchainJennifer S KoRaymond WinquistHeather C LoseyJan Joseph MelenhorstBrian R Gastman

Published in: Journal for immunotherapy of cancer (2024)

Our model reproduces differential effects of immunotherapy in melanoma patients, capturing the inherent heterogeneity in clinical responses. Taken together, these data demonstrate our model's translatability for novel immunotherapies in melanoma patients. The data are also supportive for the continued clinical investigation of nemvaleukin as a novel immunotherapeutic for the treatment of melanoma.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
endothelial cells
stem cells
electronic health record
big data
single cell
mesenchymal stem cells
machine learning
artificial intelligence