Assessment of brain beta-amyloid deposition in transgenic mouse models of Alzheimer's disease with PET imaging agents 18F-flutemetamol and 18F-florbetaben.

Hye Joo SonYoung Jin JeongHyun Jin YoonSang Yoon LeeGo-Eun ChoiJi-Ae ParkMin Hwan KimKyo Chul LeeYong Jin LeeMun Ki KimKook ChoDo-Young Kang

Published in: BMC neuroscience (2018)

Compared with 18F-flutemetamol images, 18F-florbetaben images showed prominent visual uptake intensity, SUVR, and higher correlations with the pathology. In contrast, 18F-flutemetamol was more actively metabolized than was 18F-florbetaben (Son et al. in J Nucl Med 58(Suppl 1):S278, 2017].

Keyphrases

pet imaging
deep learning
convolutional neural network
mouse model
optical coherence tomography
magnetic resonance
positron emission tomography
white matter
high intensity
machine learning
contrast enhanced
blood brain barrier
clinical evaluation