Bulleyaconitine A Inhibits Visceral Nociception and Spinal Synaptic Plasticity through Stimulation of Microglial Release of Dynorphin A.
Sheng-Nan HuangJinbao WeiLan-Ting HuangPei-Jun JuJinghong ChenYong-Xiang WangPublished in: Neural plasticity (2020)
These results suggest that BAA produces visceral antinociception by stimulating spinal microglial release of dynorphin A, which activates presynaptic κ-opioid receptors in afferent neurons and inhibits spinal synaptic plasticity, highlighting a novel interaction mode between microglia and neurons.