Login / Signup

Synthetic DNA binders for fluorescent sensing of thymine glycol-containing DNA duplexes and inhibition of endonuclease activity.

Yusuke SatoYoshihide TakakuToshiaki NakanoKen AkamatsuDai InamuraSeiichi Nishizawa
Published in: Chemical communications (Cambridge, England) (2023)
Dimethyllumazine (DML)-thiazole orange (TO) conjugates were developed for fluorescence sensing of thymine glycol (Tg)-containing DNAs based on the selective recognition of the A nucleobase opposite the Tg residue. Additionally, this conjugate has demonstrated an inhibitory activity towards endonuclease III, a DNA repair enzyme, through its competitive binding to Tg-containing DNAs.
Keyphrases
  • dna repair
  • single molecule
  • dna damage
  • circulating tumor
  • cell free
  • dna damage response
  • living cells
  • cancer therapy
  • quantum dots