Evolution of Castration-Resistant Prostate Cancer in ctDNA during Sequential Androgen Receptor Pathway Inhibition.

Matti AnnalaSinja TaavitsainenDaniel J Khalaf Gillian VandekerkhoveKevin BejaJoonatan SipolaEvan W WarnerCameron HerbertsAmanda WongSimon FuDaygen L FinchConrad D OjaJoanna VergidisMuhammad ZulfiqarBernhard J EiglChristian K KollmansbergerMatti NykterMartin E GleaveKim N ChiAlexander W Wyatt

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Our data show that the dominant AR genotype continues to evolve during sequential lines of AR inhibition and drives acquired resistance in patients with mCRPC.

Keyphrases

electronic health record
machine learning
circulating tumor
data analysis
circulating tumor cells