A water-soluble fluorescent organic nano-photosensitizer for the ratiometric detection of mitochondrial G-quadruplexes with photodynamic therapy potential.
Qing-Yu MaXiang LiWei ZhouXia-Fen LiYi-Chen LiuGai-Li FengHongwei TanYuan ZhangGuo-Wen XingPublished in: Chemical communications (Cambridge, England) (2023)
We report a water-soluble AIEgen (TPAL) that can self-assemble into fluorescent organic nanoparticles for the ratiometric detection of mitochondrial DNA (mtDNA) parallel G-quadruplexes (G4s) with high selectivity, a low detection limit and photodynamic therapy (PDT) potential.
Keyphrases
- water soluble
- photodynamic therapy
- mitochondrial dna
- label free
- quantum dots
- living cells
- copy number
- fluorescence imaging
- loop mediated isothermal amplification
- fluorescent probe
- sensitive detection
- real time pcr
- hydrogen peroxide
- oxidative stress
- gene expression
- risk assessment
- nitric oxide
- human health
- climate change