Sensitive electrochemiluminescence (ECL) immunoassays for detecting lipoarabinomannan (LAM) and ESAT-6 in urine and serum from tuberculosis patients.

Tobias BrogerMichael TsionksyAnu MathewTodd L LowaryAbraham PinterTatiana PlisovaDaniel BartlettSimone BarberoClaudia M DenkingerEmmanuel MoreauKiyonori KatsuragiMasanori KawasakiPayam NahidGeorge B Sigal

Published in: PloS one (2019)

LAM and ESAT-6 can be detected in the urine and serum of TB patients, regardless of the HIV status and further gains in clinical sensitivity may be achievable through assay and reagent optimization. Accuracy in urine was higher with current methods and has the potential to meet the WHO accuracy target if the findings can be transferred to a point-of-care TB test.

Keyphrases

end stage renal disease
mycobacterium tuberculosis
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
emergency department
antiretroviral therapy
hiv aids
sensitive detection
climate change
quantum dots