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Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress.

Ken UekawaYorito HattoriSung Ji AhnJames SeoNicole CaseyAntoine AnfrayPing ZhouWenjie LuoJosef AnratherLaibaik ParkCostantino Iadecola
Published in: Molecular neurodegeneration (2023)
and ameliorated CAA without affecting parenchyma plaques. Lack of CD36 enhanced the vascular clearance of exogenous Aβ. Restoration of neurovascular function and attenuation of CAA resulted in a near complete rescue of cognitive function. Collectively, these data implicate brain BAM in the pathogenesis of CAA and raise the possibility that targeting BAM CD36 is beneficial in CAA and other conditions associated with vascular Aβ deposition and damage.
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