Bone metabolism genes variation and response to bisphosphonate treatment in women with postmenopausal osteoporosis.

Pavel MarozikVidmantas AleknaEma RudenkoMarija TamulaitieneAlena RudenkaAsta MastaviciuteVolha SamokhovecAndrejus CernovasKatsiaryna KobetsIrma Mosse

Published in: PloS one (2019)

Our findings highlight the importance of identified single gene variants and their allelic combinations for pharmacogenetics of BPs therapy of osteoporosis. Complex screening of these genetic markers could be used as a new strategy for personalized antiresorptive therapy.

Keyphrases

bone mineral density
postmenopausal women
genome wide
copy number
stem cells
gene expression
replacement therapy
mesenchymal stem cells
smoking cessation