Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies.

Savanna Wallin Yongseok Choi Gloria E O Borgstahl Amarnath Natarajan

Published in: bioRxiv : the preprint server for biology (2023)

An 8-step synthesis was used to generate a biotinylated-mitoxantrone probe (MXP).A pulldown of MXP demonstrated selectivity for RAD52, but not Replication Protein A.Western blot confirmed the identity of the isolated protein, RAD52.

Keyphrases

dna damage
dna repair
living cells
protein protein
binding protein
amino acid
small molecule