Evodiamine Selectively Inhibits Multiple Myeloma Cell Growth by Triggering Activation of Intrinsic Apoptosis Pathway.

Published in: OncoTargets and therapy (2019)

We provided evidence to demonstrate that Evo selectively suppresses cell growth and increases apoptosis rate in MM cells through the intrinsic apoptosis pathway. Application of Evo and bortezomib might enhance the anti-cancer effect on MM cells.

Keyphrases

cell cycle arrest
cell death
induced apoptosis
endoplasmic reticulum stress
pi k akt
multiple myeloma
oxidative stress
signaling pathway
cell proliferation