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Identification of a novel RPGR mutation associated with retinitis pigmentosa and primary ciliary dyskinesia in a Slovak family: a case report.

Zuzana KolkovaPeter DurdikVeronika HolubekovaAnna DurdikovaMilos JesenakPeter Banovcin
Published in: Frontiers in pediatrics (2024)
gene expands the spectrum of genetic variants associated with the X-linked PCD phenotype overlapping with RP, highlighting the diversity of mutations contributing to the disorder. The described genotype-phenotype correlation can be useful in clinical practice to recognise a broader spectrum of PCD phenotypes as well as for future research focused on the genetic basis of PCD, gene interactions, the pathways implicated in PCD pathogenesis, and the role of RPGR protein for the proper functioning of cilia in various tissues throughout the body.
Keyphrases
  • genome wide
  • copy number
  • clinical practice
  • dna methylation
  • current status
  • amino acid
  • small molecule