Decreasing dorsal cochlear nucleus activity ameliorates noise-induced tinnitus perception in mice.

Thawann MalfattiBarbara CiralliMarkus M HilscherRichardson N LeaoKatarina E Leão

Published in: BMC biology (2022)

We found that lowering DCN activity in mice displaying tinnitus-related behavior reduces tinnitus, but lowering DCN activity during noise exposure does not prevent noise-induced tinnitus. Our results suggest that CaMKII α-positive cells in the DCN are not crucial for tinnitus induction but play a significant role in maintaining tinnitus perception in mice.

Keyphrases

hearing loss
air pollution
high fat diet induced
high glucose
diabetic rats
induced apoptosis
spinal cord
drug induced
type diabetes
skeletal muscle
adipose tissue
wild type
cell cycle arrest
oxidative stress
mouse model
cell death