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Cytotoxicity phenylpropanoid amides from the seed of Cannabis sativa L.

Ao-Fei WangJuan PanXiang LiuXin-Yuan LiPeng JiangMeng-Meng LiWei GuanQing-Shan ChenLi-Li ZhangHai-Xue KuangYan LiuBing-You Yang
Published in: Natural product research (2024)
Two novel phenylpropanoid amides, namely huomarenamide A ( 1 ) and huomarenamide B ( 2 ), along with twelve known compounds ( 3 - 14 ), were isolated from the seeds of Cannabis sativa L. The structures with absolute configurations of new compounds were unequivocally determined by spectroscopic analyses and the ECD method. The identification of the known compounds was based on a comparison of their 1D NMR data with literature references. All compounds were assessed for cytotoxic activity against LN229 cells, revealing that compounds 2 , 13 , and 14 exhibited significant cytotoxicity with IC 50 values ranging from 9.02 to 21.26 μM.
Keyphrases
  • high resolution
  • induced apoptosis
  • molecular docking
  • electronic health record
  • oxidative stress
  • cell death
  • artificial intelligence