Integrated case-control and somatic-germline interaction analyses of soft-tissue sarcoma.

Fulan HuYao YuJiun-Sheng ChenHao HuPaul ScheetChad D Huff

Published in: Journal of medical genetics (2020)

Our results confirm that pathogenic variants in NF1, RB1 and TP53 confer large increases in the risk of developing multiple STS subtypes, provide support for the role of MSH2 in STS susceptibility and identify BAG1 as a novel candidate STS risk gene.

Keyphrases

copy number
case control
signaling pathway
genome wide
lps induced
oxidative stress
nuclear factor
dna methylation
gene expression
dna damage