Rho family GTPase 1 (RND1), a novel regulator of p53, enhances ferroptosis in glioblastoma.

Qian SunYang XuFan'en YuanYangzhi QiYixuan WangQianxue ChenBao-Hui Liu

Published in: Cell & bioscience (2022)

We found that RND1, a novel controller of p53 protein and a positive regulator of p53 signaling pathway, enhanced the ferroptosis in GBM. This study may shed light on the understanding of ferroptosis in GBM cells and provide new therapeutic ideas for GBM.

Keyphrases

cell death
cell cycle arrest
induced apoptosis
signaling pathway
transcription factor
pi k akt
endoplasmic reticulum stress
epithelial mesenchymal transition
binding protein
small molecule
smooth muscle