Mitochondrial protection by simvastatin against angiotensin II-mediated heart failure.

Chong-Chao HsiehChia-Yang LiChih-Hsin HsuHsiu-Lin ChenYung-Hsiang ChenYu-Peng LiuYu-Ru LiuHsuan-Fu KuoPo-Len Liu

Published in: British journal of pharmacology (2019)

Mitochondria play a key role in mediating heart failure progression. Simvastatin attenuated heart failure, induced by angiotensin II, via mitochondrial protection and might provide a new therapy to prevent heart failure.

Keyphrases

angiotensin ii
heart failure
angiotensin converting enzyme
vascular smooth muscle cells
left ventricular
oxidative stress
cardiac resynchronization therapy
acute heart failure
atrial fibrillation
stem cells
cell death
bone marrow
chemotherapy induced