Progressive alterations in white matter microstructure across the timecourse of Huntington's disease.
Carlos Estévez-FragaMichael S ElmalemSarah J TabriziAlexandra DürrElin M ReesNicola Z HobbsRaymund A C RoosGeorg Bernhard LandwehrmeyerBlair R LeavittDouglas R LangbehnRachael I ScahillGeraint ReesSarah J TabriziSarah GregoryPublished in: Brain and behavior (2023)
The present study showed significant longitudinal changes in WM microstructure across the HD timecourse. Changes were evident in larger WM areas and across more metrics as the disease advanced, suggesting a progressive alteration of WM microstructure with disease evolution.
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