Hypertension and atrial fibrillation: the clinical impact of hypertension on perioperative outcomes of atrial fibrillation ablation and its optimal control for the prevention of recurrence.
Masashi KamiokaKeisuke NaritaTomonori WatanabeHiroaki WatanabeHisaki MakimotoTakafumi OkuyamaAyako YokotaTakahiro KomoriTomoyuki KabutoyaYasushi ImaiKazuomi KarioPublished in: Hypertension research : official journal of the Japanese Society of Hypertension (2024)
Hypertension (HTN) is one of the major risk factors for developing atrial fibrillation (AF), and it has been estimated that approximately 70% of hypertensive patients are at risk of developing AF. On the other hand, 60-80% of AF patients have HTN. These two diseases share many risk factors such as diabetes mellitus, obesity, alcohol consumption, and sleep apnea syndrome during their onset and disease progression. The mutual presence of these diseases has the potential to create a negative spiral, exacerbating each other's impact and ultimately leading to cardiovascular events such as heart failure and cerebrovascular disorders, thereby increasing mortality rates. With regard to the treatment of HTN, the variety of antihypertensive drugs and treatment options have significantly increased. Alongside the widespread adoption of antihypertensive therapy, a certain level of efficacy has been recognized in suppressing the incidence of new-onset AF. Catheter ablation is an established and effective treatment for AF. However, a notable recurrence rate persists. In recent years, management of these multiple risk factors has been recognized to be essential for suppressing AF recurrence, and recent guidelines for AF underscore the significance of proactively managing these risks before treatment. Notably, effective HTN management assumes paramount importance given its impact on the morbidity of AF patients. This review summarizes the correlation between HTN control before and after ablation and the risk of AF recurrence. The focus is on elucidating the pathophysiological background and its impact on clinical outcomes.
Keyphrases
- atrial fibrillation
- catheter ablation
- blood pressure
- heart failure
- left atrial
- risk factors
- oral anticoagulants
- left atrial appendage
- cardiovascular events
- hypertensive patients
- direct oral anticoagulants
- end stage renal disease
- ejection fraction
- percutaneous coronary intervention
- sleep apnea
- newly diagnosed
- metabolic syndrome
- coronary artery disease
- cardiovascular disease
- alcohol consumption
- chronic kidney disease
- prognostic factors
- stem cells
- patients undergoing
- replacement therapy
- obstructive sleep apnea
- signaling pathway
- patient reported outcomes
- acute kidney injury
- left ventricular
- mesenchymal stem cells
- adipose tissue
- radiofrequency ablation
- combination therapy
- arterial hypertension