Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves' ophthalmopathy.
Jae Yeon KimSohae ParkHyun-Jung LeeHelen LewGi Jin KimPublished in: Stem cell research & therapy (2020)
In summary, IGFBPs secreting PD-MSCPRL-1 inhibit adipogenesis in OFs from GO patients by upregulating phosphorylated FAK and downregulating PI3K/AKT/mTOR signaling pathway. The functional enhancement of PD-MSCs by nonviral gene modification provides a novel therapeutic strategy for the treatment of degenerative diseases.
Keyphrases
- signaling pathway
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- mesenchymal stem cells
- peritoneal dialysis
- prognostic factors
- pi k akt
- copy number
- metabolic syndrome
- genome wide
- dna methylation
- cell proliferation
- bone marrow
- high fat diet induced
- adipose tissue
- combination therapy
- replacement therapy
- endoplasmic reticulum stress
- patient reported