Energy expenditure deficits drive obesity in a mouse model of Alström syndrome.

Erin J StephensonClint E KinneyAmanda S StaytonJoan C Han

Published in: Obesity (Silver Spring, Md.) (2023)

Either loss of ALMS1 causes a developmental delay in the mechanisms controlling early life EE or activation of compensatory mechanisms occurs after obesity is established in AS. Future studies will determine how ALMS1 modulates EE and how sex moderates this process.

Keyphrases

early life
insulin resistance
mouse model
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
traumatic brain injury
adipose tissue
current status
case report